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KMID : 0545120230330050621
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Journal of Microbiology and Biotechnology
2023 Volume.33 No. 5 p.621 ~ p.633
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Anti-Obesity Potential through Regulation of Carbohydrate Uptake and Gene Expression in Intestinal Epithelial Cells by the Probiotic Lactiplantibacillus plantarum MGEL20154 from Fermented Food
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Park So-Young
Choi Jin-Won
Oh Dong-Nyoung
Lee Eun-Ji
Kim Dong-Pil
Yoon Sun-Jay
Jang Won-Je
Han Sang-Jun
Lee Seung-Jun
Lee Jong-Min
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Abstract
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We investigated the probiotic characteristics and anti-obesity effect of Lactiplantibacillus plantarum MGEL20154, a strain that possesses excellent intestinal adhesion and viability. The in vitro properties, e.g., gastrointestinal (GI) resistance, adhesion, and enzyme activity, demonstrated that MGEL20154 is a potential probiotic candidate. Oral administration of MGEL20154 to diet-induced obese C57BL/6J mice for 8 weeks resulted in a feed efficacy decrease by 44.7% compared to that of the high-fat diet (HFD) group. The reduction rate of weight gain was about 48.5% in the HFD+MGEL20154 group compared to that of the HFD group after 8 weeks, and the epididymal fat pad was also reduced in size by 25.2%. In addition, the upregulation of the zo-1, pparα, and erk2, and downregulation of the nf-κb and glut2 genes in Caco-2 cells by MGEL20154 were observed. Therefore, we propose that the anti-obesity effect of the strain is exerted by inhibiting carbohydrate absorption and regulating gene expression in the intestine.
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KEYWORD
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Lactiplantibacillus plantarum MGEL20154, anti-obesity, erk2, pparα, glut2
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